1,2-二油酰-sn-甘油-3-磷酰乙醇胺 , 98%
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 98%
分子式: C41H78NO8P
分子量: 744.03
纯度: 98%
| 包装 | 库存 | 价格 | |
|---|---|---|---|
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基本信息
英文别名1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine | |
中文别名2-氨乙基 (R)-2,3-二(2-油酰氧)丙基磷酸氢酯 | |
MDL编码MFCD00057986 | Reaxys-RN (Beilstein)1718431 |
安全信息
存储条件Freezer -20℃ | WGK Germany3 |
TSCA0 | |
化学和物理性质
MP200 |
产品描述
产品描述
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。
靶点（IC50 & Targe）
IC50: helper lipid for liposome[1]
体外研究
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].
With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].
LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].
LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
