(R)-巴氯芬 , 98% , 是选择性 GABAB 受体激动剂
(R)-Baclofen, 98%, a selective GABAB receptor agonist
分子式: C10H12ClNO2
分子量: 213.66
纯度: 98%
| 包装 | 库存 | 价格 | |
|---|---|---|---|
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推荐产品
基本信息
英文别名(R)-4-Amino-3-(4-chlorophenyl)butyric acid | |
中文别名(R)-4-氨基-3-(4-氯苯基)丁酸 | |
MDL编码MFCD01321057 |
安全信息
存储条件Freezer -20℃ | Symbol   |
Signal WordWarning | Hazard StatementsH302 H410 |
Precautionary StatementsP264 P270 P330 P501 P273 P391 P301+P317 | |
UN3077 | Hazard Class9 |
Packing GroupIII | WGK Germany3 |
TSCA0 | |
化学和物理性质
产品描述
产品描述
(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。
靶点（IC50 & Targe）
GABAR
体外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
参考文献
[1] Falch E, et al. J Neurochem, 1986, 47(3), 898-903.
[2] Penn RD, et al. Lancet, 1984, 1(8385), 1078.
