| 包装 | 库存 | 价格 | |
|---|---|---|---|
暂无数据 | |||
基本信息
安全信息
存储条件Freezer -20℃ | Symbol   |
Signal WordWarning | Hazard StatementsH302 H410 |
Precautionary StatementsP264 P270 P330 P501 P273 P391 P301+P317 | |
UN3077 | Hazard Class9 |
Packing GroupIII | TSCA0 |
化学和物理性质
产品描述
产品描述
UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM. IC50 value: 4 nM [1] Target: G9a UNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/function ratios in these cell lines.
靶点（IC50 & Targe）
G9a
参考文献
[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.
