手性配体新品推荐，结构多样，还有前沿科研成果供应-百灵威

设计和合成高催化活性和高选择性的手性催化剂是不对称催化的关键，其中手性配体是催化剂产生不对称诱导和控制的重要来源。本文对四类常见手性配体进行简要介绍。

手性联萘配体

1979年，Noyori首次将B,B'-联萘酚用作手性配体催化醛、酮的还原反应，并开创性地发展了联萘双膦配体（BINAP），新型联萘基轴手性配体不断被开发出来并且应用在过渡金属催化的不对称合成反应中，其中具有C2对称轴的联萘酚（BINOL）、联萘酚胺（NOBIN）、联萘胺（BINAM）是三类常用的手性源。

Josiphos配体

Josiphos配体是一类以二茂铁为骨架的的配体，由Togni课题组于1987年首次制备，并将在烯酰胺的催化氢化反应中展现出优异的对映选择性和催化活性（ee＞90%）。Josiphos配体具有合成简单，底物范围广，官能团兼容性好，对映选择性、收率和催化活性高等优点，其开拓性仅次于BINAP配体。

手性噁唑啉配体

手性噁唑啉杂环化合物是一种常用的手性配体，自1986年首次应用于不对称催化以来，被广泛应用于金属催化的不对称反应中，如Diels-Alder二烯环加成反应、Michael缩合反应、Friedel-Crafts反应、Aldol缩合反应等，不对称催化活性和对映选择性优异，因而受到广泛的关注。

手性氮杂卡宾配体

氮杂环卡宾（NHC）配体与有机膦配体类似，都是强σ电子供体，氮杂卡宾的金属络合物具有良好的热稳定性，耐氧性和耐湿性，使反应条件多变得更加的温和。催化反应时不用像有机膦配体那样加入过量的配体来保证反应有效进行。1983年，Lappert等人首次合成了含有手性基团的NHC，此后大量单齿和双齿的手性氮杂环卡宾（NHC）配体被合成出来，并广泛的应用于不对称催化反应中。

百灵威近期新上线各种手性配体及前沿科研成果，满足您的不同需求：

主要包括手性联萘配体、Josiphos配体、噁唑啉配体、NHC配体等；
可提供华东师范大学周剑教授团队研发的12种不同取代基的手性吡啶双噁唑啉（PYBOX）配体。

手性联萘配体

品名	CAS	货号
(R)-2,2''-Bis(bromomethyl)-1,1''-binaphthalene, 97%, ee: 98% (R)-2,2''-双(溴甲基)-1,1''-双萘	86631-56-3	1737525
(R)-2,2'-Dibromo-1,1'-binaphthalene, 97%, ee: 98% (R)-2,2'-二溴-1,1'-联萘酚	86688-08-6	632908
(R)-N,N'-Dimethyl-1,1'-binaphthyldiamine, 97% (R)-N,N'-二甲基-1,1'-联萘二胺	93713-30-5	807287
(S)-2,2'-Bis(bromomethyl)-1,1'-binaphthalene, 97%, ee: 98% (S)-2,2'-二(溴甲基)-1,1'-联萘	37803-02-4	2743035
(S)-2,2'-Dibromo-1,1'-binaphthalene, 97%, ee: 98% (S)-2,2'-二溴-1,1'-联萘酚	150024-49-0	632757
(S)-N,N'-Dimethyl-1,1'-binaphthyldiamine, 97% (S)-N,N′-二甲基-1,1′-联萘二胺	666175-40-2	807285
(R)-[1,1'-Binaphthalene]-2,2'-diylbis[1,1-diphenyl-1,1'-phosphine oxide], 97%, ee: 98% (R)-[1,1'-联萘]-2,2'-二基双[1,1-二苯基氧膦]	94041-16-4	2740685
(S)-[1,1''-Binaphthalene]-2,2''-diylbis[1,1-diphenyl-1,1''-phosphine oxide], 97%, ee: 98% (S)-[1,1'-联萘]-2,2'-二基双-[1,1-二苯基氧膦]	94041-18-6	2740686

品名	CAS	货号
(S)-(+)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine, 97% (S)-(+)-1-[(R)-2-(二苯基膦)二茂铁]乙基二环己基膦	162291-02-3	318726
(S)-1-[(RP)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine, 97% (S)-1-[(RP)-2-(二环己基膦基)二茂铁]乙基二叔丁基膦	1246841-00-8	2406633
(S)-1-[(RP)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldiphenylphosphine, 97% (S)-1-[(RP)-2-(二叔丁基膦)二茂铁]乙基二苯基膦	223121-01-5	622890
(R)-1-[(SP)-2-(Di-tertbutylphosphino)ferrocen yl]ethylbis(2-methylphenyl)phosphine, 97% (R)-1-[(SP)-2-(二叔丁基膦)二茂铁基]乙基双(2-甲基苯基)膦	849924-76-1	622891

品名	CAS	货号
2,6-Bis[(4R,5R)-4,5-dihydro-1-[[(4-methylphenyl)sulfonyl]-4,5-diphenyl-1H-imidazol-2-yl]-Pyridine, 97% 2,6-双[(4R,5R)-4,5-二氢-1-[[(4-甲基苯基)磺酰基]-4,5-二苯基-1H-咪唑-2-基]吡啶	863491-57-0	9188769
2,2-Bis[(4S)-4-benzyl-2-oxazolin-2-yl]propane, 97%, ee: 98% 2,2-双[(4S)-4-苄基-2-恶唑啉-2-基]丙烷	176706-98-2	2698483
(R,R)-2,2'-Isopropylidenebis(4-isopropyl-2-oxazoline), 97%, ee: 98% (R,R)-2,2'-亚异丙基双(4-异丙基-2-恶唑啉)	150529-94-5	2572012
(S,S)-2,2'-Isopropylidenebis(4-isopropyl-2-oxazoline), 97%, ee: 98% (S,S)-2,2'-异亚丙基(4-异丙基-2-恶唑啉)	131833-92-6	789224
(4S,4'S,5R,5'R)-2,2'-(1-Methylethylidene)bis[4,5-dihydro-4,5-diphenyloxazole], 97%, ee: 98% (4S,4'S,5R,5'R)-2,2'-(1-甲基亚乙基)双[4,5-二氢-4,5-二苯基噁唑]	157825-96-2	9108707
(4R,4'R)-2,2'-[2-Phenyl-1-(phenylmethyl)ethylidene]bis[4-(1-methylethyl)-4,5-dihydrooxazole], 97%, ee: 98% (4R,4'R)-2,2'-[2-苯基-1-(苯甲基)亚乙基]双[4-(1-甲基乙基)-4,5-二氢噁唑]	880479-99-2	9222355
(4R,4'R)-2,2'-Cyclopentylidenebis[4,5-dihydro-4-(phenylmethyl)oxazole], 97%, ee: 98% (4R,4'R)-2,2'-环亚戊基双[4,5-二氢-4-苄基噁唑]	2005443-99-0	9108708
(4S,4'S)-2,2'-Cyclopentylidenebis[4,5-dihydro-4-phenyloxazole], 97%, ee: 98% (4S,4'S)-2,2'-环亚戊基双[4,5-二氢-4-苯基噁唑]	1639791-77-7	9075822
(3aS,3a'S,8aR,8a'R)-2,2'-(Cyclopentane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole), 97%, ee: 98% (3aS,3a'S,8aR,8a'R)-2,2'-(环戊烷-1,1-二基)双(8,8a-二氢-3αH-茚并[1,2-d]噁唑)	182122-12-9	2740954
(4R,4'R)-2,2'-Cyclopentylidenebis[4,5-dihydro-4-isopropyloxazole], 97%, ee: 98% (4R,4'R)-2,2'-环戊亚基双[4,5-二氢-4-异丙基噁唑]	1379452-53-5	9188731
(3aR,3a'R,8aS,8a'S)-2,2'-Cyclohexylidenebis[8,8a-dihydro-3aH-indeno[[1,2-d]oxazole], 97%, ee: 98% (3aR,3a'R,8aS,8a'S)-2,2'-亚环己基双[8,8a-二氢-3aH-茚并[[1,2-d]噁唑]	2097145-89-4	9222412
(3aS,3a'S,8aR,8a'R)-2,2'-Cyclohexylidenebis[8,8a-dihydro-3aH-indeno[[1,2-d]oxazole], 97%, ee: 98% (3aS,3a'S,8aR,8a'R)-2,2'-环己亚基双[8,8a-二氢-3aH-茚并[[1,2-d]噁唑]	182122-13-0	9108713
(4S,4'S)-2,2'-Cyclohexylidenebis[4,5-dihydro-4-(phenylmethyl)oxazole], 97%, ee: 98% (4S,4'S)-2,2'-环己亚基双[4,5-二氢-4-苯甲基噁唑]	1003886-07-4	9188730
(4R,4'R)-2,2'-(Cyclohexane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole), 97%, ee: 98% (4R,4'R)-2,2'-(环己烷-1,1-二基)双(4-苯基-4,5-二氢噁唑)	2271404-99-8	9222284
(4S,4'S)-2,2'-Cyclohexylidenebis[4,5-dihydro-4-isopropyloxazole], 97%, ee: 98% (4S,4'S)-2,2'-环已亚基双[4,5-二氢-4-异丙基噁唑]	1373357-00-6	9188734
(4S,4'S)-2,2'-(4,6-Dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole], 98% (4S,4'S)-2,2'-(4,6-二苯并呋喃二基)双[4,5-二氢-4-苯基恶唑]	246040-77-7	9191145
4,6-Bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan, 97% 4,6-双((S)-4-异丙基-4,5-二氢噁唑-2-基)二苯并[b,d]呋喃	409312-96-5	9189366
2-[(4R)-4,5-Dihydro-4-(phenylmethyl)-2-oxazolyl]pyridine, 97%, ee: 98% 2-[(4R)-4,5-二氢-4-(苯甲基)-2-恶唑基]吡啶	1108603-35-5	9188717
2-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]pyridine, 97%, ee: 98% 2-[(4R)-4,5-二氢-4-异丙基-2-噁唑啉基]吡啶	132187-16-7	9188722
(S)-4-tert-Butyl-2-(2-pyridyl)oxazoline, 98% (S)-4-叔丁基-2-(2-吡啶基)恶唑啉	117408-98-7	1682830
2-[(4R)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine, 97%, ee: 98% 2-[(4R)-4-(1,1-二甲基乙基)-4,5-二氢-2-噁唑基]-5-(三氟甲基)吡啶	1428537-19-2	1947980
2-[(4S)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine, 97%, ee: 98% 2-[(4S)-4-(1,1-二甲基乙基)-4,5-二氢-2-噁唑基]-5-(三氟甲基)吡啶	1416819-91-4	1528294
1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4R)-4,5-二氢-4-异丙基-2-噁唑基]异喹啉	280755-83-1	9108698
1-[(4S)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4S)-4,5-二氢-4-异丙基-2-噁唑基]异喹啉	1701405-00-6	9108699
1-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4R)-4-叔丁基-4,5-二氢-2-噁唑基]异喹啉	1402851-53-9	9191073
1-[(4S)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]isoquinoline, 97%, ee: 98% 1-[(4S)-4-叔丁基-4,5-二氢-2-噁唑基]异喹啉	1402851-52-8	9108700
(S)-2-(Isoquinolin-1-yl)-4-phenyl-4,5-dihydrooxazole, 97%, ee: 98% (S)-2-(异喹啉-1-基)-4-苯基-4,5-二氢噁唑	2058236-53-4	9222362
(S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, 97%, ee: 98% (S)-4-苄基-2-(异喹啉-1-基)-4,5-二氢噁唑	2058236-52-3	9222267
(R)-(-)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline, 97%, ee: 98% (R)-(-)-2-[2-(二苯基膦)苯基]-4-苯基-2-噁唑啉	167171-03-1	618984
(4R)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)oxazole, 97%, ee: 98% (4R)-2-[2-(二苯膦基)苯基]-4,5-二氢-4-(苯基甲基)噁唑	314020-70-7	9188726
(S)-4-Benzyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole, 97%, ee: 98% (S)-4-苄基-2-(2-(2-(二苯基膦基)苯基)-4,5-二氢恶唑	148461-13-6	9130982

周剑教授团队科研成果｜新型苄氧基、膦酸酯基、砜基PYBOX配体
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氮杂卡宾配体

品名	CAS	货号
(5S)-5,6-Dihydro-5-(phenylmethyl)-2-(2,4,6-trimethylphenyl)-8H-1,2,4-triazolo[3,4-c][1,4]oxazinium tetrafluoroborate, 97%, ee: 98% (5S)-5,6-二氢-5-(苯甲基)-2-(2,4,6-三甲基苯基)-8H-1,2,4-三唑并[3,4-c][1,4]噁嗪四氟硼酸盐	950842-73-6	9189356
(5S)-5,6-Dihydro-2-(2,3,4,5,6-pentafluorophenyl)-5-(phenylmethyl)-8H-1,2,4-triazolo[3,4-c][1,4]oxazinium tetrafluoroborate, 97%, ee: 98% (5S)-5,6-二氢-2-(2,3,4,5,6-五氟苯基)-5-(苯基甲基)-8H-1,2,4-三唑并[3,4-c][1,4]噁嗪四氟硼酸盐	1327274-33-8	9187147
6,7-Dihydro-2-pentafluorophenyl-5H-pyrrolo[2,1-c][1,2,4]triazolium tetrafluoroborate, 98% 6,7-二氢-2-五氟苯基-5H-吡咯并[2,1-c][1,2,4]三唑鎓四氟硼酸盐	862095-91-8	789335

品名	CAS	货号
(1S,2S)-N,N-Bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine, 97%, ee: 98% (1S,2S)-N,N-双[2-(二苯基膦)苄基]环己烷-1,2-二胺	174677-83-9	1001047
(R,R)-DACH-pyridyl Trost ligand, 97%, ee: 98% (R,R)-DACH-吡啶基 Trost 配体	218290-24-5	310494
(1S,2S)-N,N'-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide), 97%, ee: 98% (1S,2S)-N,N'-双(2-吡啶甲酰) -1,2-环己二胺	172138-95-3	125413
N,N'-[(1R,2R)-1,2-Diphenyl-1,2-ethanediyl]bis[2-diphenylphosphinobenzamide], 95%, ee: 98% N,N'-[(1R,2R)-1,2-二苯基-1,2-乙二基]双[2-二苯基膦苯甲酰胺]	138517-62-1	9188779
(2R,3R)-1,4-Dioxaspiro[4.5]decane-2,3-diylbis(diphenylmethanol), 95%, ee: 98% (2R,3R)-1,4-二氧杂螺[4.5]癸烷-2,3-二基双(二苯基甲醇)	114026-76-5	2081531
(2S,3S)-1,4-Dioxaspiro[4.5]decane-2,3-diylbis(diphenylmethanol), 95%, ee: 98% (2S,3S)-1,4-二氧杂螺[4.5]癸烷-2,3-二基-双(二苯基甲醇)	123287-35-4	2081532
((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol), 95%, ee: 98% ((4R,5R)-2,2-二甲基-1,3-二氧戊环-4,5-二基)双(二(萘-1-基)甲醇)	137536-94-8	566457
((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol), 95%, ee: 98% ((4S,5S)-2,2-二甲基-1,3-二氧戊环-4,5-二基)双(二(萘-1-基)甲醇)	171086-52-5	620564
(S)-1-(2-(Diphenylphosphino)phenyl)ethylamine, 97%, ee: 98% (S) -1-(2-(二苯基膦基)苯基)乙胺	913196-43-7	1000989
2,2',3,3'-Tetrahydro-1,1'-spirobi[indene]-7,7'-diol, 97%, ee: 98% 2,2',3,3'-四氢-1,1'-螺二[1H-茚]-7,7'-二醇	223137-87-9	1382043