硒代蛋氨酸（Se-Met）是一种硒的有机形态，与蛋氨酸类似。目前硒代蛋氨酸的生物学研究日趋成熟，可作为医药保健品中间体、饲料添加剂等来调控机体的自由基代谢、抗氧化功能、免疫功能、生殖功能、细胞凋亡和激素分泌^[1-2]。
    在蛋白质研究领域中，硒代蛋氨酸可在不影响蛋白质功能情况下完全替代蛋氨酸，且其衍生物晶体与天然蛋白晶体同晶，用于经典相位确定法——“同晶置换法”进行蛋白结构分析^[3-4]。蛋白质研究中的硒代蛋氨酸标记还可在模型构建时助力确认蛋氨酸残基位点^[5-6]。

    百灵威提供L-硒代蛋氨酸产品，品质优良，现货稳定供应：
高纯度，97%以上；
质量有保障：HPLC检测方法验证；

产品列表

品名	CAS	货号
L-Selenomethionine, 97% L-硒代蛋氨酸	3211-76-5	207744

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DL-Dithiothreitol, 98%, for bio DL-二硫苏糖醇	3483-12-3	963376
Sodium dodecyl sulfate, 99%, for biochemistry 十二烷基硫酸钠	151-21-3	105893
Glycerol, 99%, for bio 甘油	56-81-5	921371
Tris(hydroxymethyl)aminomethane, 99.5%, extra pure 三(羟甲基)氨基甲烷	77-86-1	226162
Sodium chloride, 99.5%, molecular biology grade 氯化钠	7647-14-5	908606
DL-Dithiothreitol, 98%, for bio DL-二硫苏糖醇	3483-12-3	963376
Ampicillin sodium salt 氨苄青霉素钠	69-52-3	947040
Kanamycin sulfate, an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes 硫酸卡那霉素	25389-94-0	357211
Sodium hydroxide, 96%, for analysis, flaky 氢氧化钠	1310-73-2	904646 危化品
α-Toluenesulfonyl fluoride, 98.5% α-甲苯基磺酰氟	329-98-6	945600

参考文献

1. Siyu Li,Zhaorong Ouyang,Mengjie Zhang, et al.Selenomethionine-Conjugated Extracellular Vesicles for ROS-Mediated Cell Apoptosis[J].ACS Applied Nano Materials,2024, 7(12): 20.
2. Jun Chen,Yinzhi Zhang,Yantao Lv,et al.Effects of Selenomethionine on Cell Viability,Selenoprotein Expression and Antioxidant Function in Porcine Mammary Epithelial Cells[J]. Frontiers in Nutrition,2021,8:665855.
3. Rebecca Notis Dardashti,Norman Metanis, et al.Revisiting ligation at selenomethionine: Insights into native chemical ligation at selenocysteine and homoselenocysteine[J]. Bioorganic & Medicinal Chemistry,2017,25(18): 4983-4989.
4. Daniele de Sanctis, Paul A Tucker, Santosh Panjikar, et al. Additional phase information from UV damage of selenome­thionine labelled proteins[J]. Journal of Synchrotron Radiation,2011,18: 374-380.
5. John Q Bettinger, Kevin A Welle, Jennifer R Hryhorenko, et al. Quantitative Analysis of in Vivo Methionine Oxidation of the Human Proteome[J].Journal of Proteome Research ,2019, 19 (2).
6. Ronnie P.-A. Berntsson, Nur Alia Oktaviani,Fabrizia Fusetti,et al.Selenomethionine incorporation in proteins expressed in Lactococcus lactis[J].Protein Science,2009,18(5): 1121-1127.

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