卟啉衍生物已被广泛应用于催化领域。金属卟啉为细胞色素P-450的模拟物，可实现高选择性和低催化剂负载；在多种化学反应中，可进行C-H氧化功能化、环氧化、硫化物转化为亚砜氧化，而无需使用易爆的有机过氧酸、强无机酸或有毒的金属羰基配合物。游离碱卟啉也可用于光氧化还原催化。

应用实例

选择性C-H叠氮化 Reported by the Groves group: J. Am. Chem. Soc. 2015, 137, 5300-5303

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选择性C-H氟化 Reported by the Groves group: Nature Protocols 2013, 8, 2348-2354

Reported by the Groves group: Angew. Chem. Int. Ed. 2018, 57, 1251-1255

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环氧化

Reported in: Org. Biomol. Chem. 2008, 6, 4494-4497

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卟啉作为光敏剂，形成内过氧化物

Reported by the Groves group: J. Am. Chem. Soc. 2011, 133, 8150-8153

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叠氮化物分子内C-H胺化

Reported by the de Bruin group: Chem. Eur. J. 2017, 23, 7945-7952

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通过吲哚的C-H官能化合成色胺

Reported by the Koenigs group: Angew. Chem. Int. Ed. 2019, 58, 3630-3634

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炔烃的顺式选择性加氢

Reported by the Matsubara group: Synlett 2014, 25, 1287-1290

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酚的氧化偶联

Reported by the Guo group: Eur. J. Org. Chem. 2013, 10, 1861-1866

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用原位生成的三氟甲基重氮甲烷进行环丙烷化

Reported by the Carreira group: Angew. Chem. Int. Ed. 2010, 49, 938-941

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氯金四苯基卟啉对联烯酮的环异构化

Reported by the Che group: Org. Lett. 2006, 8, 325-328

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利用四苯基氯卟啉铬将环氧化物羰基化

Reported by the Ibrahim group: Org. Lett. 2011, 13, 3142-3145