Negishi Cross-Coupling

时间: Invalid Date
作者: 百灵威
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Negishi Cross-Coupling-百灵威

The use of organozinc reagents in the Negishi (Pd- or Ni-catalyzed) cross-coupling reaction with organohalides allows for a much greater functional group tolerance than in the Kumada cross-coupling reaction. Other benefits include high reactivity, high regio- and stereoselectivity, few side reactions and little toxicity. Unlike the addition of a base in the Suzuki cross-coupling reaction, additives are not required to boost reactivity. The mechanism follows the expected oxidative addition-reductive elimination cycle.

  • Reagents: Catalytic Palladium or Nickel, Ligand (PPh3, dppe, dppp, dppb, dppf, etc.)
  • Reactant: Organohalide, Organozinc
  • Product: Coupled product
  • Type of Reaction: C-C Cross-Coupling
Mechanism
Original Paper
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  • Fukuyama Coupling
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