穿越微观，准确捕捉——纳米材料在生物传感器中的应用
时间: 2024-08-19
作者: 百灵威
分享:
生物传感器是一种将生物识别元件与物理传感器结合的装置，用于检测和分析生物分子，如蛋白质、核酸、酶、抗体、细胞、组织和微生物等。通过将这些生物分子与特定的化学或物理检测系统相结合，能够实现对生物化学过程的快速、准确、灵敏监测。
纳米材料的特点能够满足生物传感器多功能、微型化、高速化的发展需求，能够大幅度提升生物分子或者细胞的检测灵敏度，且可实现高通量实时检测分析。
金属纳米颗粒
金属纳米颗粒良好的电子传递性能使其成为电化学生物传感器中十分常用的纳米材料之一，其中金、银纳米颗粒最为常用。 金纳米颗粒金纳米颗粒具有高比表面积、良好的生物相容性和催化活性，既可用于光化学传感器也可用于电化学传感器。
| 品名 | CAS | 货号 |
|---|---|---|
| Gold nanoparticles citrate-coated, 50 μg/mL dispersion in water, diam.: 80±8 nm, λ: 535 - 550 nm, O.D.: >0.6 金纳米粒子柠檬酸修饰 | 7440-57-5 | 968346 |
| Au@SiO2 nanoparticles, 0.05 mg/mL in ultrapure water, Au=60nm, thickness of SiO2: 50nm, surface group: SiO2 Au@SiO2纳米颗粒 | / | 9229053 |
| Gold nanorods modified with PEG, 0.1 mg/mL in ultrapure water, surface group: —PEG—COOH, λ=660±15nm PEG化金纳米棒 | 7440-57-5 | 967334 |
| Gold nanorods modified with PEG, 0.1 mg/mL in ultrapure water, surface group: —PEG—COOH, λ=800±15nm PEG化金纳米棒 | 7440-57-5 | 921860 |
| Gold nanorods modified with PEG, 0.1 mg/mL in ultrapure water, surface group: —PEG—NH2, λ=610±15nm PEG化金纳米棒 | 7440-57-5 | 902198 |
| Gold nanorods modified with PEG, 0.1 mg/mL in ultrapure water, surface group: —PEG—NH2, λ=790±15nm PEG化金纳米棒 | 7440-57-5 | 990739 |
| Au@SiO2 nanoparticles, 0.05 mg/mL in ultrapure water, Au=15nm, thickness of SiO2: 25nm, surface group: SiO2 Au@SiO2纳米颗粒 | / | 9229037 |
银纳米颗粒具有较强吸附性、良好的生物相容性和优异导电性。银纳米颗粒可通过对目标检测物进行电催化放大电信号，提高检测灵敏度。也可与氧化剂的结合，通过阳极溶出伏安法对阴离子进行电化学检测。
| 品名 | CAS | 货号 |
|---|---|---|
| Silver nanowires, 99.5%, 5 mg/mL dispersion in isopropanol, diam.: 18 - 22 nm, length: 15-20 μm 银纳米线 | 7440-22-4 | 971108 |
| Silver nanowires, 99.9%, 10 mg/mL dispersion in ethanol, diam.: 28 – 32 nm, length: ≥2 – 20 μm 银纳米线 | 7440-22-4 | 992893 |
| Silver nanowires, 98%, 20 mg/mL dispersion in water, diam.: 40 nm, length: 20 - 60 μm 银纳米线 | 7440-22-4 | 908663 |
| Water soluble silver nanoparticles, 0.1 mg/ml 水溶性银纳米颗粒 | / | 9229054 |
| Oil soluble silver nanoparticles, 0.1 mg/mL in in xylenes, d=20±3nm, surface group: arene 油溶性银纳米颗粒 | / | 9229069 |
| Silver nanoparticles modified with PEG, 0.1 mg/mL in ultrapure water, d=20±3nm, surface group: —PEG—COOH PEG化银纳米颗粒 | / | 9229093 |
| Silver nanoparticles modified with PEG, 0.1 mg/mL in ultrapure water, d=30±5nm, surface group: —PEG—NH2 PEG化银纳米颗粒 | / | 9229082 |
| Silver nanoparticles modified with streptavidin, 0.1 mg/mL in ultrapure water, d=20±3nm, surface group: SA 链霉亲和素修饰的银纳米颗粒 | / | 9229104 |
| Silver nanoparticles modified with streptavidin, 0.1 mg/mL in ultrapure water, d=40±5nm, surface group: SA 链霉亲和素修饰的银纳米颗粒 | / | 9229106 |
| 品名 | CAS | 货号 |
|---|---|---|
| Platinum nanoparticles, 0.2 mg/mL in ultrapure water, d=2-3nm, surface group: —NH2 铂纳米颗粒 | / | 9251299 |
| Monodispersed magnetite microspheres, 99.5%, 20 nm 四氧化三铁 | 1317-61-9 | 978495 |
| Oleic acid coated Fe3O4 magnetic nanoparticles, 1 mg/mL Fe dispersion in hexane, diam.: 10 ± 3 nm 油酸修饰的四氧化三铁纳米粒子 | 1317-61-9 | 901693 |
| Fe3O4 nanoparticles modified with PEG, Fe: 1 mg/mL in ultrapure water, d=10±5nm, surface group: —NH2 PEG化四氧化三铁磁性纳米颗粒 | 1317-61-9 | 979969 |
| Fe3O4 nanoparticles modified with PEG, Fe: 1 mg/mL in ultrapure water, d=10±5nm, surface group: —OCH3 PEG化四氧化三铁磁性纳米颗粒 | 1317-61-9 | 928403 |
| Fe3O4 nanoparticles modified with PEI, Fe: 1 mg/mL in ultrapure water, d=10±5nm, surface group: —NH2 聚乙烯亚胺修饰的四氧化三铁磁性纳米颗粒 | 1317-61-9 | 991381 |
| Fe3O4 nanoparticles modified with oleic acid, Solid powder,d=10±5nm, surface group: OA, high-temperature pyrolysis method 油酸修饰的四氧化三铁磁性纳米颗粒 | 1317-61-9 | 989591 |
| Iron oxide(II,III), magnetic nanoparticles solution, amino-polyacrylamide functionalized, particle size:20nm, 5 mg/ml in H2O 四氧化三铁磁性纳米粒子溶液 | 1317-61-9 | 9020742 |
碳纳米管
碳纳米管具有较大管间吸引能，可以快速调节电子转移动力学，促进直接电子转移，被广泛用作电化学生物传感器的支持电极基质。此外，其表面可通过各种化学基团修饰捕获更多生物分子。| 品名 | CAS | 货号 |
|---|---|---|
| Arc-discharge-grown single-walled carbon nanotubes, Carbon tube content: 30-40%, diam: 1.2 - 1.7 nm, length: 400nm - 5 μm 电弧法单壁碳纳米管 | 1333-86-4 | 112060 |
| Purified arc-discharge-grown single-walled carbon nanotubes, Carbon tube content: 60-70%, diam: 1.2 - 1.7 nm, length: 400nm - 5 μm 高纯电弧法单壁碳纳米管 | 1333-86-4 | 990858 |
| Carbon nanotubes, multi-walled, 99%, reagent grade, inner diam.: 2 -5 nm, outer diam.: 5 - 15 nm, length: 10 - 30 μm 碳纳米管, 多壁式 | 308068-56-6 | 927177 |
| Carbon nanotubes, multi-walled, 99.9%, reagent grade, inner diam.: 3 - 5 nm, outer diam.: 8 - 15 nm, length: 10 - 50 μm 碳纳米管, 多壁式 | 308068-56-6 | 983835 |
| Carbon nanotubes, multi-walled, NH2 functionalized, 95%, reagent grade, inner diam.: 3 - 5 nm, outer diam.: 8 - 15 nm, length: approx. 50 μm 碳纳米管, 多壁式, 氨基官能化 | 308068-56-6 | 742602 |
| Carbon nanotubes, multi-walled, hydroxy functionalized, 98%, reagent grade, outer diam.: 5 - 15 nm, length: 10 - 30 μm 碳纳米管, 多壁式, 羟基官能化 | 308068-56-6 | 989275 |
| Carbon nanotubes, multi-walled, carboxylic acid functionalized, 99%, outer diam.:5-15 nm, length:10-30 um 碳纳米管, 多壁式, 羧酸官能化 | 308068-56-6 | 974689 |
石墨烯
石墨烯及其氧化物是一种具有高导电性、高化学稳定性和高比表面积的碳纳米材料，在电化学传感器中有广泛应用。在生物传感器电极界面的构建中石墨烯或石墨烯衍生物常用来对电极界面进行改性，从而降低过电位，增强电流响应.
| 品名 | CAS | 货号 |
|---|---|---|
| Graphene oxide, 4 mg/mL dispersion in water 氧化石墨烯 | 1034343-98-0 | 909428 |
| Single layer graphene oxide, single layer ratio: approx. 90%, diam.: 0.5 - 5 μm, thickness: 0.8 - 1.2 nm 单层氧化石墨烯 | 1034343-98-0 | 933162 |
| Monolayer graphene on Cu substrate, 10 mm x 10 mm Cu基质的单层石墨烯 | 1034343-98-0 | 914100 |
| Graphene -OH functionalized Graphene, 98%, diam.: 0.5 - 3 μm, thickness: 0.55 - 3.74 nm, layers：≤10 羟基功能化石墨烯 | 1034343-98-0 | 904945 |
| Graphene -COOH functionalized Graphene, 98%, diam.: 0.5 - 3 μm, thickness: 0.55 - 3.74 nm, layers：≤10 羧基功能化石墨烯 | 1034343-98-0 | 926928 |
| Graphene -NH2 functionalized, 98%, diam.: 0.5 - 3 μm, thickness: 0.55 - 3.74 nm, layers：≤10 氨基功能化石墨烯 | 1034343-98-0 | 932270 |
| Graphene quantum dots, 1 mg/mL dispersion in water, fluorescence: λem 520 nm 石墨烯量子点 | 1034343-98-0 | 998621 |
| Carboxyl functional graphene quantum dots, 1 mg/mL dispersion in water, fluorescence: λem 487 nm 羧基化石墨烯量子点 | 1034343-98-0 | 909651 |
| Graphene oxide quantum dots, 1 mg/mL dispersion in water, fluorescence: λem 470 nm 氧化石墨烯量子点 | 1034343-98-0 | 963545 |
| Hydroxy functional graphene quantum dots, 1 mg/mL dispersion in water, fluorescence: λem 420 nm 羟基化石墨烯量子点 | 1034343-98-0 | 980868 |
| Amino functional graphene quantum dots, 1 mg/mL dispersion in water, fluorescence: λem 442 nm 氨基化石墨烯量子点 | 1034343-98-0 | 999133 |
导电聚合物
| 品名 | CAS | 货号 |
|---|---|---|
| Poly(methyl methacrylate), Average Mw ~13,000 - 17,000 (GPC) 聚(甲基丙烯酸甲酯) | 9011-14-7 | 914311 |
| PEDOT: PSS（CLEVIOS™ P VP AI 4083）, from Heraeus PEDOT: PSS, 型号为4083 | 155090-83-8 | 927751 |
| POLYDIMETHYLSILOXANE TRIMETHYLSILOXY TERMINATED cSt 100 聚二甲基硅氧烷, 三甲基硅氧烷封端, M.W. 14,000 | 9016-00-6 | DMS-T21 |
| Polydimethysiloxanetrimethylsiloxy terminated cSt20 聚二甲基硅氧烷 | 9016-00-6 | DMS-T12 |
| Polyacrylamide (10% in H2O, Technical Grade) 聚丙烯酰胺，阴离子，1000-1200万 | 9003-05-8 | P688150 |
| Polyvinylpyrrolidone, Molecular weight: 40000 ~ 45000 聚乙烯吡咯烷酮 | 9003-39-8 | 932394 |
| Polypyrrole (undoped, extent of labeling: ~20 wt. % loading, composite with carbon black) 聚吡咯(未掺杂，标记范围：~20重量%负载，与炭黑复合) | 30604-81-0 | P698945 |
| Poly(3-hexylthiophene-2,5-diyl), average M.W. 45000 聚(3-己基噻吩-2,5-二基) | 104934-50-1 | 986833 |
导电聚合物复合材料用掺杂剂
| 品名 | CAS | 货号 |
|---|---|---|
| 3-Aminopropyltrimethoxysilane, 97% 3-氨基丙基三甲氧基硅烷 | 13822-56-5 | 566905 |
| Benzyldimethyldodecylammonium chloride, 98% 十二烷基二甲基苄基氯化铵 | 139-07-1 | 975757 |
| Bismuth(III) nitrate pentahydrate, 98% 硝酸铋(III)五水合物 | 10035-06-0 | 541584 危化品 |
| Chloroplatinic acid hexahydrate, 99.9%, trace metals basis, 38 - 40% Pt 氯铂酸六水合物 | 18497-13-7 | 111781 危化品 |
| Citric acid, 98%, anhydrous 柠檬酸 | 77-92-9 | 947677 |
| 1-Dodecanesulfonic acid sodium salt, 99% 1-十二烷基磺酸钠盐 | 2386-53-0 | 319432 |
| 1-Dodecanethiol, 98% 1-十二硫醇 | 112-55-0 | 443671 危化品 |
| 1-Dodecylpyridinium chloride, 98% 1-十二烷基氯化吡啶 | 104-74-5 | 103145 |
| 4-Dimethylaminopyridine, 99% 4-二甲氨基吡啶 | 1122-58-3 | 117147 |
| Gallium(III) acetylacetonate (99.99+%-Ga) PURATREM 乙酰丙酮镓 | 14405-43-7 | 93-3130 |
| Gallium(III) nitrate hydrate (99.99%-Ga) PURATREM 硝酸镓水合物 | 69365-72-6 | 93-3105 危化品 |
| Molybdenum(IV) sulfide, 99% 硫化钼(IV) | 1317-33-5 | 279238 |
| Monostearin, 60% 单硬酯酸甘油酯 | 123-94-4 | 273770 |
| N-[3-(Trimethoxysilyl)propyl]ethylenediamine, 95% N-[3-(三甲氧基硅基)丙基]乙二胺 | 1760-24-3 | 137935 |
| N-Doecyldimethyl(3-sulfopropyl)ammonium hydroxide, 99% N-十二烷基二甲基(3-磺丙基)氢氧化铵 | 14933-08-5 | 947659 |
| Nonafluoro-1-butanesulfonic acid, 98% 全氟-1-丁磺酸 | 375-73-5 | 387933 |
| N-Tetradecylphosphonic acid, 95% N-四癸基磷酸 | 4671-75-4 | 372605 |
| 1-Octadecene, 97% 1-十八烯 | 112-88-9 | 987298 |
| 3-(1-Pyridinio)-1-propanesulfonate, 97% 3-(1-吡啶)-1-丙磺酸钠 | 15471-17-7 | 918497 |
| Perfluoroheptanoic acid, 98% 全氟庚酸 | 375-85-9 | 607925 |
| Perfluorononanoic acid, 98% 全氟壬酸 | 375-95-1 | 243503 |
| Platinum(II) acetylacetonate, 49% Pt, Product of Umicore 乙酰丙酮铂(II) | 15170-57-7 | 900235 |
| Poly(ethylene glycol), average M.W. 1,000 聚乙二醇 | 25322-68-3 | 967105 |
| 聚乙烯磺酸钠 溶液 聚乙烯磺酸钠 溶液 | 9002-97-5 | 278424 |
| Polyethylene glycol dodecyl ether, high purity grade 月桂醇聚氧乙烯醚 | 9002-92-0 | 214944 |
| Polyoxyethylene(23) lauryl ether, 30% w/v solution in H2O 月桂醇聚氧乙烯(23)醚 | 9002-92-0 | 908502 |
| Span 20 司班20 | 1338-39-2 | 996749 |
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