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Derivatization is the process by which a compound is chemically changed, producing a new compound that has properties more amenable to a particular analytic technique. As a key separation method, derivatization provides:
  • Increased volatility, thermal stability, and peak shape
  • Improved selectivity and chromatographic efficiency
  • Strengthened detectability

J&K provides an extensive selection of Derivatization Reagents, including those used for GC and HPLC analysis, chiral separations and TLC applications. By choosing the right derivatization reagent and procedure you can increase resolution and analytic response, significantly improving your separations.

GC Derivatization Reagents

GC Derivatization Reagents include silylation reagents, acylation reagents, esterification & alkylation reagents and others.


Cat. No.
Bis(dimethylamino)dimethylsilane, 97%
N,O-Bis(trimethylsilyl)acetamide, 95%
N,O-Bis(trimethylsilyl)trifluoroacetamide, 98%
Bromotrimethylsilane, 98%
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, 97%
Chloro(chloromethyl)dimethylsilane, 98%
Dichlorodiethylsilane, 97%
N,N-Dimethyltrimethylsilylamine, 97%, derivatization grade
Heptamethyldisilazane, 98%
N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97%
1,1,3,3-Tetramethyldisilazane, 97%
N-Trimethylsilylimidazole, 98%


Cat. No.
1-Acetylimidazole, 98%
Bistrifluoroacetamide, 98%
Heptafluorobutyric acid, 99%
Heptafluorobutyric anhydride, 98%
1-(Heptafluorobutyryl)imidazole, 97%
(±)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 97%
N-Methyl-bis(trifluoroacetamide), 98%
1-(Trifluoroacetyl)imidazole, 97.5%, derivatization grade

● Esterification & Alkylation

Cat. No.
2,2-Dimethoxypropane, 98%
N,N-Dimethylformamide diethyl acetal, 95%
N,N-Dimethylformamide dimethyl acetal, 95%
Methyl trifluoromethanesulfonate, 0.96%
Tetramethylammonium hydroxide, 25% solution in H2O
3-(Trifluoromethyl)phenyltrimethylammonium hydroxide, 5% solution in MeOH
(Trimethylsilyl)diazomethane, 2.0 M solution in hexanes
Trimethylsulfonium hydroxide, 0.25 M solution in MeOH

● Others

Cat. No.
n-Butylboronic acid, 98%
O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride, 99%, derivatization grade

Chiral Derivatization Reagents
Chiral GC Derivatization Reagents

Cat. No.
(-)-Camphanic acid chloride, 98%
(R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 98%, ee: 99.5%
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 98%
(R)-(+)-1-(1-Naphthyl)ethylamine, 99%
(S)-(-)-1-(1-Naphthyl)ethylamine, 99%
L-(-)-2-Octanol, 99%
D-(+)-2-Octanol, 99%
(R)-(+)-1-Phenylethanol, 99%, for chiral derivatization
(S)-(-)-1-Phenylethanol, 99%, for chiral derivatization
(R)-(+)-1-Phenylethylamine, 99%
(S)-(-)-1-Phenylethylamine, 99%, ee: 98%
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