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Green chemistry has become a central focus of chemical research and development in the 21st century. Some of the most widely used reagents, such as NXS (including NBS, NCS and NIS), produce reactions that are ‘greener’ than traditional reactions with Cu catalysts in halogenation. There are also many common reagents which are harmful and/or create pollution so chemists are constantly working to generate alternate ‘green’ reagents to satisfy growing demand from academia and industry.
 
We understand that chemistry is a tool for scientific research and manufacturing, but this tool comes with a duty to make our world a better place – one with cleaner oceans, fresher air and safer food. J&K is proud to provide environmentally friendly green reagents, including synthetic reagents, solvents, catalysts & ligands.

■ Green Synthetic Reagents

● Featured Products:
1.    Caro’s acid (Potassium peroxomonosulfate, 4.5% active oxygen, 229941, 37222-66-5)
 

 

Reference 1: Caro’s acid with acetone for epoxide formation: Angew. Chem. Int. Ed., 2012, 51(10), 2443-2447
Reference 2: Caro’s acid for sulfones formation: Bioorg. Med. Chem.Lett., 2012, 22(15), 5114-5117
Reference 3 - 5: Caro’s acid with MX for C-X formation: Org. Lett., 2013, 15(24), 6226-6229; Tetrahedron Lett.,2014, 55(13), 2127-2129; Synthetic Commun.,2002, 32(15), 2319-2324
 
1.    MMPP (Magnesium bis(monoperoxyphthalate) hexahydrate, 70%, 566277, 84665-66-7)
 2.1MMPP for epoxide formation:

 2.2MMPP for N-Oxide formation:

 

3.    NFSI(N-Fluorobenzenesulfonimide, 98%, 115351, 133745-75-2) for fluorination:
4.    Hantzch ethyl ester (Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, 98%, 505196, 1149-23-1) for reduction:
 
5.    COMU((1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino
-carbenium hexafluorophosphate, 98%, 1150273, 1075198-30-9) for amide formation:

 

 

 

6.    DPAT (Diphenylammoniumtrifluoromethanesulfonate, 98%, 802121, 164411-06-7) for one pot ring closing:
 

Cat. No.
Description
CAS
Uses
Caro’s acid (Potassium peroxomonosulfate, 4.5% active oxygen)
C-X Formation & Oxidation
NFSI (N-Fluorobenzenesulfonimide, 98%)
C-F Formation
NBS (N-Bromosuccinimide, 99%)
C-Br Formation
NCS (N-Chlorosuccinimide, 97.5%)
C-Cl Formation & Oxidation
NIS (N-Iodosuccinimide, 99%)
C-I Formation
PhNMe3Br3 (Phenyltrimethylammoniumtribromide, 97%)
C-Br Formation
Py·HBr3(Pyridiniumtribromide, 90%)
C-Br Formation
5% NaClO (Sodium hypochlorite, 5% available chlorine)
C-Cl Formation & Oxidation
13% NaClO (Sodium hypochlorite, 13% available chlorine)
C-Cl Formation & Oxidation
Dichlorodimethylhydantoin (1,3-Dichloro-5,5-dimethylhydantoin, 98%)
C-Cl Formation
Dichlorodimethylhydantoin (1,3-Dichloro-5,5-dimethylhydantoin, 68% available chlorine)
C-Cl Formation
Oxalylchloride, 98%
C-Cl Formation & Oxidation& Amide (Ester) Formation
Phenyl dichlorophosphate, 97%
C-Cl Formation
Me4NF (Tetramethylammonium fluoride tetrahydrate, 98%)
C-F Formation
Bis(2-methoxyethyl)aminosulphurtrifluoride, 95%
C-F Formation
4-tert-Butyl-2,6-dimethylphenylsulphur trifluoride, 90%
C-F Formation
ICl (Iodine monochloride, 99%)
C-I Formation
BenzyltrimethylammoniumDichloroiodiate, 98%
C-I Formation
Sodium percarbonate
Oxidation
Urea-Hydrogen peroxide, contains 35 wt.% H2O2, stabilized
Oxidation
TEMPO (2,2,6,6-Tetramethylpiperidinooxy, 98%)
Oxidation
SO3-Pyridine
(Sulfur trioxide pyridine complex, 98%, tech., active SO3 ca. 48 - 50%)
Oxidation
Stabilized IBX
(2-Iodoxybenzoic acid, stabilized)
Oxidation
Al(Ot-Bu)3
(Aluminum tert-butoxide, 99%)
Oxidation
DCC (N,N'-Dicyclohexylcarbodiimide, 99%) (with DMSO, 935690, 67-68-5)
Oxidation
NaIO4 (Sodium periodate, 99%)
Oxidation
MMPP (Magnesium bis(monoperoxyphthalate) hexahydrate, 70%)
Oxidation
Hantzch ethyl ester (Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, 98%)
Reduction
Catecholborane, 1.0 M solution in THF, J&KSeal
Reduction
Formic acid, 98%
Reduction
COMU ((1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate, 98%)
Amide Foramtion
CDI (N,N'-Carbonyldiimidazole, 98%)
Amide Formation
i-BuOCOCl (Isobutyl chloroformate, 98%)
 
Amide Formation
Mukaiyama reagent (2-Chloro-1-methylpyridinium iodide, 97%)
Amide Formation& Ester Formation
SuOCOOSu (N,N'-Disuccinimidyl carbonate, 99%)
Amide Formation
TFFH(N,N,N',N'-Tetramethylfluoroformamidiniunhexafluorophosphate, 97%)
Amide Formation
EEDQ (N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 98%)
Amide Formation
EDCI (N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, 99%)
Amide Formation
CDMT(2-Chloro-4,6-dimethoxy-1,3,5-triazine, 97%)
Amide Formation
DBU(1,8-Diazabicyclo[5.4.0]undec-7-ene, 98%)
Ether Formation
DPAT (Diphenylammoniumtrifluoromethanesulfonate, 98%)
Others

■ Green Solvents

● 2-Methyl-tetrahydrofuran (2-MeTHF) can be derived from renewable resources (e.g., furfural or levulinic acid) and is a promising alternative solvent in the search for environmentally benign synthesis strategies.
 
● Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. Wide synthetic utility and a detailed toxicity study suggest CPME as a green and sustainable solvent of choice for modern chemical transformations.
 
Reference:
1) 2-Methyltetrahydrofuran (2-MeTHF): a biomass-derived solvent with broad application in organic chemistry, ChemSusChem.,2012, 5(8), 1369-1379;
2) The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent, Molecules, 2013, 18, 3183-3194
 
Cat. No.
Description
CAS
2-Methyltetrahydrofuran, 99%, stabilized with BHT
2-Methyltetrahydrofuran, 99%, SuperDry, J&KSeal
Cyclopentyl methyl ether, 99%
Please also see
Ionic Liquid - Page **
Catalysts & Ligands - Page **
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