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Highly reactive four-membered ring compounds including cyclobutane ,oxetane, azetidine .They are useful substrates in organic chemistry due to the functionalization of the different positions of the ring which can be used to design and preparation of biologically active compounds. For example, L-azetidine-2-carboxylic acid(237409) is an inhibitor of collagen synthesis as anti-angiogenic. The best-known examples of oxetane-containing drugs are the natural product paclitaxel (Taxol®) and its synthetic analog docetaxel. Joëlle Dubois and co-workers studied the effect of the deletion of the oxetane ring in analogs of docetaxel and found the analogs were less active than docetaxel in biological assays.

The four-membered ring compounds have become standard elements of the repertoire of chemists in drug discovery. This has resulted in an strong growth of the number of journals or patents across a wide range of applications.
 
 
J&K can offer a variety of four-membered ring compounds in different package sizes from grams to kilograms. All these products have sufficient stockand are known for their excellent quality and competitive prices.

■ Cyclobutanes & Cyclobutenes

Cat. No.
Description
CAS
Pack Size
Bromocyclobutane, 97%
250 mg/1 g/5 g
Cyclobutylamine, 98% 
1 mL/5 mL
Cyclobutanol, 99% 
1 g/5 g/25 g
Cyclobutanone, 98% 
1 g/5 g/25 g
(Bromomethyl)cyclobutane, 98.5%
5 mL /25 mL
Cyclobutanemethanol, 99% 
5 g/25 g
Cyclobutanecarboxylic acid, 98% 
1 g/5 g/25 g
3-Oxo-cyclobutanecarboxylic acid, 95%
1 g/5 g/25 g
1,1-Cyclobutanedicarboxylic acid, 99%
5 g/25 g/100 g
3,4-Dihydroxy-3-cyclobutene-1,2-dione, 99%
5 g/25 g
3,4-Dimethoxy-3-cyclobutene-1,2-dione, 99%
1 g/5 g
3,4-Dibutoxy-3-cyclobutene-1,2-dione, 98%
1 g/5 g/25 g
3,4-Diethoxy-3-cyclobutene-1,2-dione, 98%
1 g/5 g/25 g

■ Oxetanes

Cat. No.
Description
CAS
Pack Size
Oxetan-3-one, 95%
500 mg/1g/5 g
β-Propiolactone, 98%, research grade
5 mL/25 mL
3-Ethyl-3-oxetanemethanol, 98%
25 g/100 g
N-Boc-L-serine β-lactone, 98%
1 g

■ Azetidines

Cat. No.
Description
CAS
Pack Size
Azetidine, 95%
250 mg/1 g/5 g
Azetidine hydrochloride, 99%
1 g/5 g/25 g
Azetidine-3-carboxylic acid, 98%
1 g/5 g/25 g
3-Hydroxyazetidine hydrochloride, 97%
1 g/5 g
L-Azetidine-2-carboxylic acid, 98%
50 mg/250 mg
Azetidine-3-carbonitrile hydrochloride, 97%
1 g/5 g
1-Boc-3-azetidinone, 98%
250 mg/1 g/5 g
N-Boc-azetidine-3-carboxylic acid, 97%
1 g/5 g
1-Boc-3-aminoazetidine, 97%
250 mg/1 g
1-Benzhydryl-azetidine-3-carbonitrile, 97%
500 mg/5 g
1-(Diphenylmethyl)-3-hydroxyazetidine, 98%
1 g/5 g/25 g

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